【摘要】 目的探讨凋亡抑制因子survivin和c-myc在食管鳞癌(ESC)组织中的表达及其与临床病理因素之间的关系。方法应用免疫组织化学SP法和Power VisionTM-9000(PV-9000)法检测60例ESC,15例食管良性肿瘤和10例癌旁正常食管黏膜组织中survivin和c-myc的表达。结果60例ESC中survivin和c-myc的阳性表达率分别为71.67%和61.67%,与食管良性肿瘤和癌旁食管正常黏膜组织比较均有显著性差异(2χ=16.29、23.45,P<0.001)。survivin和c-myc的表达强度与ESC的分化程度、临床分期和淋巴结转移有关(Hc=2.24~16.03,P<0.05),与肿瘤长度及部位无关(Hc=0.04~0.51,P>0.05)。survivin与c-myc的表达呈显著正相关(r=0.60,P<0.01)。结论survivin和c-myc均与ESC的发生发展有关,二者在ESC的发展过程中可能起协同作用。联合检测survivin和c-myc在ESC中表达水平,对判定食管癌恶性程度及预后可能具有重要参考价值。更多还原

【Abstract】 ObjectiveTo study the expression of survivin,c-myc and their significance in esophageal squamous cell carcinoma（ESCC）.MethodsThe expression of survivin and c-myc was detected immunohistochemically by SP and Power Vision^TM-9000（PV-9000） methods in 60 cases of ESCC,15 cases of esophageal benign tumor and 10 cases of adjacent normal esophageal mucosa.ResultsThe positive expression rate of survivin and c-myc in ESC was 71.67% and 61.67%,respectively.There was significant difference between ESCC and esophageal benign tumor,adjacent normal mucosa（χ²=16.29,23.45;P<0.001）.The expressive intensity of survivin and c-myc correlated with histopathological grade,clinical stage and lymph node metastasis（H_c=2.24-16.03,P<0.05）,but no correlation with the location and the length of ESC（H_c=0.04-0.51,P>0.05）.The expression of survivin and c-myc showed significant correlation（r=0.60,P<0.01）.ConclusionSurvivin and c-myc may play certain roles in the oncogensis and progression of ESCC,and work together in the development of the disease.Combined detection of the expression of survivin and c-myc may be useful for evaluating its infiltration,metastasis and prognosis.更多还原