【摘要】 目的:观察锰剂对Ⅱ型糖尿病大鼠心肌的保护作用并探讨其机制。方法:以高糖高脂饲料饲喂后的雄性SD大鼠小剂量尾静脉注射STZ诱导Ⅱ型糖尿病模型,将实验动物分为正常组、糖尿病组、补锰组,检测各组喂养6周、10周、14周的血糖水平,检测第14周后心肌组织中丙二醛(M DA)含量及锰-超氧化物歧化酶(M n-SOD)活性。结果:与糖尿病组相比,补锰各组心肌组织M DA含量明显下降(P<0.01),而M n-SOD活性明显上升(P<0.01、P<0.005和P<0.05)。结论:补锰可以改善Ⅱ型糖尿病大鼠的心肌抗氧化能力。更多还原

【Abstract】 Objective: Protection roles of Manganese on myocardium of Ⅱ diabetic rat were observed and their mechanisms were explored.Method: Experimental animals were divided in three groups: the control groups,the diabetic groups and supplying Manganese groups.When the rats were fed in 6 weeks,10 weeks and 14 weeks,we detected blood sugar level of every groups.In 14 weeks,MDA content of myocardium tissue and Mn-SOD activities were examined.Result: Compare to the diabetic groups,supplying Manganese groups can decrease significantly MDA(P<0.01) content of myocardium tissue,but increase significantly Mn-SOD(P<0.01,P<0.005和P<0.05) activities.Conclusion: supplying Manganese can improve myocardial injury of Ⅱ diabetes.Roles of supplying Manganese were related to accelerate anti-oxidation action.更多还原