【摘要】 目的探讨急性白血病(AL)患者骨髓单个核细胞肺耐药蛋白(LRP)的表达及意义。方法采用LRP单克隆抗体、流式细胞技术分别测定15例单纯缺铁性贫血患者(对照组)和65例AL患者(AL组)LRP的表达率。结果LRP的表达率在初治和复发/难治急性淋巴细胞白血病(ALL)患者分别高于初治和复发/难治急性髓细胞白血病(AM L)患者(P均<0.05);AM L中M5亚型表达率高于M3亚型(P<0.05)。初治及复发/难治LRP(+)者缓解率明显低于LRP(-)者(P<0.05)。结论LRP的表达与AL患者临床预后密切相关,化疗前检测LRP表达率有助于个体化治疗和预测疗效。更多还原

【Abstract】 [Objective] To detect the expression and clinical value of lung resistance protein（LRP） in bone marrow mononuclear cells of acute leukemia（AL） patients.[Methods] The expression rate of LRP was detected by its monoclonal antibody and flow cytometry in 15 asiderotic anemia patients and 65 AL patients.[Results] The expression rate of LRP in initial and relapse/refractory acute lymphocytic leukemia（ALL） patients were significantly higher than that in corresponding acute myelocytic leukemia（AML） patients（P<0.05）.The expression rate of LRP in M₅ subtype was higher than that in M₃ subtype in AML patients（P<0.05）.The remission rate of initial and relapse/refractory LRP positive patients were significantly lower than that of corresponding LRP negative patients（P<0.05）.[Conclusion] The expression of LRP is significantly related to the clinical prognosis of AL patients.Examining the expression rate of LRP before chemotherapy contributes to individual therapy and predicting effect of treatment.更多还原