【摘要】 目的:观察中药制剂复肝灵颗粒对兔CCl4肝损伤的治疗作用。方法:采用10%CCl4油溶液5 ml/kg皮下注射建立兔实验性肝损伤模型,设生理盐水对照组、CCl4模型组、复肝灵(FGL)高、中、低剂量治疗组,对血清谷草转氨酶(AST)、谷丙转氨酶(ALT)、r-谷氨酰基转移酶(r-GT)、总蛋白、白蛋白、球蛋白进行检测研究。结果:CCl4模型组体重明显降低,与生理盐水对照组相比有显著的统计学意义(P<0.01),FGL治疗组体重有所降低,但与生理盐水对照组相比无统计学意义(P>0.05);CCl4模型组兔血清AST、ALT和r-GT较生理盐水对照组和3个FGL治疗组显著增加(P<0.01);FGL 3个剂量组均能明显降低CCl4所引起的肝组织丙二醛(MDA)的升高(P<0.01);在光学和电子显微镜下显示的组织学结构,FGL治疗组与对照组相比均有明显的修复。结论:复肝灵对兔CCl4肝损伤有良好的保护作用。更多还原

【Abstract】 Objective: To study the effect of traditional Chinese medicine "Fuganling"（FGL）on liver injury induced by CCl₄ in rabbits.Methods: Experimental liver injury models of rabbits were established by hyodermic injection of CCl₄ oil solution（10%,5?ml/kg）,and then they were distributed to pumping brine group（control）,CCl₄ group,and high,median,low dose FGL group.The blood serum aspartate aminotransferase（AST）,the glutamic-pyruvic transaminase（ALT）,the r-glutamltransferase（r-GT）,the gross protein,the albumin,and the globin were tested 2 months later.Results:（1） The body weights decreased obviously in CCl₄-indued injury group compared with brine group（P<0.01）,while they decreased unconspicuously in FGL therapy groups compared with brine groups（（P>）0.05）;（2） Levels of serum AST,ALT and r-GT in CCl₄-induced injury groups increased obviously compared with FGL therapy groups（P<（0.01）;）（3） CCl₄-indued liver MDA enhance was decreased by FGL evidently（P<（0.01）;）（4） Microscope and electron microscopy revealed that the liver structure had been ameliorated in Fuganling treatment groups.Conclusion: Fuganling has obviously protection effect on liver injury.更多还原