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2,3,4,6-四-O-特戊酰基-β-D-葡萄糖基异硫氰酸酯的合成

Synthesis of 2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyl Isothiocyanate

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【Author】 ZHOU Guo-bin~1,LIU Xian-liang~2,YANG Cui-ying~1,CHEN Hui-zong~3,GONG Fang~1(1.College of chemical and Environmental Eng.,SUST,Qingdao,Shandong 266510,China;2.Periodical Office of Journal;Jiangxi Normal University,Nanchang,Jiangxi 330027,China;3.Institute of Chemistry and Chemical Engineering Jiangxi Normal University Nanchang,Jiangxi 330027,China)

【机构】山东科技大学化学与环境工程学院；江西师范大学学报杂志社；江西师范大学化学化工学院；山东科技大学化学与环境工程学院山东青岛266510；江西南昌330027；山东青岛266510；

【摘要】研究一种以D-葡萄糖为起始原料,经酰基化、溴代等反应合成葡萄糖基异硫氰酸酯类化合物的新方法,并首次合成了一种新的2,3,4,6-四-O-特戊酰基-β-D-葡萄糖基异硫氰酸酯,产物经质谱、核磁共振谱及红外光谱对其进行了结构表征。糖基异硫氰酸酯是一种重要的医药和有机合成中间体,该类化合物将在合成糖基硫脲类化合物、核苷类似物、杂环化合物、糖多肽等具有潜在药理活性的化合物中具有广阔的应用前景。更多还原

【Abstract】 A novel method for the synthesis of D-glucopyranosyl isothiocyanate by using D-glucose as the starting material through multi-step reaction has been developed and the 2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyl isothiocyanate is synthesized and characterized by MS,NMR,IR first time. The 2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyl isothiocyanate is an important pharmaceu-tical and organic intermediate which could serve as versatile intermediates for the synthesis of glycosyl derivatives such as thioureas,nucleosides,heterocyclic compounds,polypeptide,etc..更多还原

【关键词】异硫氰酸酯；医药和有机中间体； 2,3,4,6-四-O-特戊酰基-β-D-葡萄糖基异硫氰酸酯；合成；
【Key words】 isothiocyanate； pharmaceutical and organic intermediate； 2,3,4,6-tetra-O-pivaloyl-β-D-glucopyranosyl isothiocyanate； synthesis；

【基金】国家自然科学基金项目(20662005)

【文献出处】山东科技大学学报(自然科学版) ,Journal of Shandong University of Science and Technology(Natural Science) , 编辑部邮箱 ,2006年04期
【分类号】TQ460.1
【被引频次】2
【下载频次】259

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