【摘要】 雌激素受体是核受体超家族成员之一,其有两种亚型雌激素受体α和雌激素受体β。两种亚型在结构上有高度的同源性,但是组织分布和各组织成分中的表达明显不同,与配体结合后产生的生物效应也不同。二者表达及比例变化与组织的功能和病理变化有关。研究雌激素受体α和雌激素受体β的结构及其在女性生殖系统中的分布和功能,探讨其与多囊卵巢综合征的关系,对了解雌激素受体亚型的分布与功能的关系,以及分布的变异和异常调节与多囊卵巢综合征的关系都有重要意义。更多还原

【Abstract】 Estrogen receptor has two isoforms: estrogen receptor alpha and estrogen receptor beta. They are very similar in structure, but different in tissue distribution, expression in different tissues and biological effects after binding to ligand. The Changes in expression and porportion of the two isoforms are associated with the function and pathologic changes of the tissues. It is of very important significance to study the structure and distribution of the two isoforms, in addition to the function of them in female reproductive system and the relationship between PCOS and estrogen receptors for understanding relation of the distribution of ER_α and ER_β with their functons and relations of variation in their distribution and disturbant regulation with PCOS.更多还原