【摘要】 目的了解云浮市健康人群乙肝病毒(HBV)感染率及免疫水平,探讨健康人群乙型肝炎防控对策和措施。方法采集43890人健康人群血清,采用酶联免疫吸附法(ELISA)测定HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc5项标志物(HBVM),并按年龄、性别分组进行分析比较。结果HBsAg总阳性率为16.91%,其中男性为17.80%,女性为16.20%,差异有显著性(P<0.01);HBeAg总阳性率为6.46%,其中男性为6.60%,女性为6.34%,差异无显著性(P>0.05);抗-HBs总阳性率为43.03%,其中男性为35.73%,女性为48.88%,差异有显著性(P<0.01);HBVM全阴率为20.58%,其中男性为26.76%,女性为15.63%,差异有显著性(P<0.01);各年龄组间抗-HBs阳性率差异有显著性(P<0.01)。结论人群中HBV感染率高,易感者多,免疫水平较低,应加强成人乙肝疫苗接种工作,扩大免疫屏障,降低发病率。更多还原

【Abstract】 Objective To understand the hepatitis B infection rate and immunization level in healthy population in Yunfu City and discuss the measures for prevention and control of hepatitis B infection in healthy population.Methods Blood serum sample was collected from 43 890 healthy peoples and grouped according to age and gender.Enzyme-linked immuosorbent essay(ELISA)was used for detection of makers of HBsAg,Anti-HBs,HBeAg,Anti-HBe,Anti-HBc.The results were analyzed.Results The total positive rate of HBsAg was16.91%,being 17.80% in the males and 16.20% in the females,showing significant difference(P<0.01);the total positive rate of HBeAg was 6.46%,being 6.60% in the males and 6.34%in the females,without showing significant difference(P<0.05);the total positive rate of anti-HBs was 43.03%,being 35.73% in the males and 48.88% in the females,showing significant difference(P<0.01);The all negative rate of HBV marker was 20.58,being 26.76% in the males and 15.63% in the females,showing significant difference(P<0.01);there significant differences in the positive rate of anti-HBs among each age groups were observed(P<0.01).Conclusion The hepatitis B infection rate is high among ordinary population and the immunization level is low.Therefore,the work of immunization with hepatitis B vaccine in the adults be strengthened to reduce the infection rate.更多还原