【摘要】 目的以高脂血症模型大鼠研究黄酮的降血脂功效。方法采用脂代谢紊乱模型——预防性给受试物法,分别以4．0、2．0、1．0mg／kg Bw3个剂量的总黄酮(以芦丁计)连续给大鼠灌胃30d,于试验终末采血测定TC、TG及HDL-C含量。结果受试样品3个剂量组大鼠的血清胆固醇(TC)含量分别为(2．60±0．72)mmol／L、(2．03±0．34)mmol／L和(2．09±0．55)mmol／L,均低于模型对照组的(4．05±0．86)mmol／L,且差异均具有显著性(P<0．01)；样品3个剂量组的甘油三脂(TG)含量分别为(0．75±0．18)mmol／L、(0．81±0．17)mmol／L和(0．96±0．23)mmol／L,均低于模型对照组的(1．82±0．33)mmol／L,且差异均具有显著性(P<0．01)；样品3个剂量组高密度脂蛋白胆固醇(HDL-c)含量分别为(0．48±0．03)mmol／L、(0．55±0．08)mmol／L和(0．49±0．06)mmol／L,均高于模型对照组的(0．43±0．05)mmol／L,且差异均具有显著性(P<0．01或P<0．05)。结论黄酮能降低受试大鼠血清的总胆固醇和甘油三脂含量,而升高高密度脂蛋白胆固醇含量,提示具有降血脂的功效。更多还原

【Abstract】 To explore the effect of flavone in reducing blood lipids. Methods The model of metabolic disturbance of lipid-preventive tested sample was adopted. After being given flavone in dosages of 4.0、2.0 and 1.0 mg/kg BW respectively for 30 days, the contents of TC,TG and HDL-C in serum of rats were tested. Results The contents of TC in high,middle and low dosage groups were (2.60 ±0.72), (2.03±0.34)and(2.09±0.55)mmol/L respectively, all significantly lower than that of model control group(4.05±0.86)mmol/L(P<0.01); The contents of TG in high, middle and low dosage groups were (0.75±0.18), (0.81±0.17)and(0.96±0.23)mmol/L, all significantly lower than that of model control group(1.82±0.33)mmol/L (P<0.01); The contents of HDL-C in high, middle and low dosage groups were (0.48±0.03), (0.55±0.08)and(0.49±0.06) mmol/L,all significantly higher than that of model control group (0.43±0.05)mmol/L (P<0.01 or P<0.05). Conclusion Flavone possesses the effect of reducing blood lipids.更多还原