【摘要】 目的了解儿童在玩耍玩具时,在玩耍行为、生理体液(汗液和唾液)和外环境的作用下玩具中邻苯二甲酸酯类(PAEs)、双酚A(BPA)、壬基酚(NP)等环境雌激素(EEs)的溶出行为和溶出量。方法用反相高效液相色谱(RP-HPLC)作为检测手段,考察了玩具样品用量、模拟汗液和唾液用量、浸渍时间、盐浓度和乳酸(表面活性剂)浓度对溶出量的影响,并测定了5种样品1h的模拟汗液和唾液的溶出量。结果7种环境雌激素的溶出量随玩具用量、浸渍液体积、浸渍时间的增加而增加,随盐浓度和乳酸浓度的增大而减小,实际样品中均有不同程度的检出,小至0.28μg,大至24.31μg。结论儿童在玩耍塑料玩具时会暴露多种环境雌激素,应当采取适当措施保护儿童健康。更多还原

【Abstract】 Objective To explore the migration behavior and amount of seven estrogens(such as phthalatea, bisphenol, 4-nonylphenol, etc.) in simulated sweat and saliva in plastic toys when children paying with them. Methods The impact of sample dosage, amount of simulated sweat and saliva, soaking volume and time, concentration of salt, lactose concentration on the migration behavior was investigated by using reverse phase high performance liquid chromatography. Results The amount seven environmental estrogen migrated was increased along with the increase of soaking area and duration, the amount was decreased along the increase of the salt and lactose concentration. The actual detection range was from 0.28 to 24.31. Conclusion Children may be exposed to environmental estrogen and appropriate measures be taken to protect the health of the children.更多还原