【摘要】 目的探讨褪黑素对大鼠梗阻性黄疸后肠组织细胞间粘附分子-1(ICAM-1)表达的影响。方法将36只大鼠随机分为3组(每组12只):假手术对照组(SO)、梗阻性黄疸组(OJ)、褪黑素治疗组(MT)。观察各组小肠组织中ICAM-1的表达及小肠组织形态学改变,并测量肠绒毛高度和黏膜厚度。结果梗阻性黄疸组小肠组织ICAM-1的表达明显增强,肠绒毛高度、黏膜厚度明显降低,与假手术对照组有显著性差异(P<0.01,P<0.01);褪黑素治疗组与梗阻性黄疸组比较小肠组织ICAM-1的表达明显减弱(P<0.01),肠绒毛高度、黏膜厚度增高,肠组织结构损害减轻(P<0.01)。结论褪黑素通过抑制梗阻性黄疸后肠组织ICAM-1的表达,减轻小肠黏膜的损伤。更多还原

【Abstract】 Objective To investigate effect of melatonin on the expression of intercellular adhesion molecule-1(ICAM-1) in intestinal tissues after obstructive jaundice in rats.Methods 36 rats were randomly into three groups: sham operated group(SO)- obstructive jaundice group (OJ)- melatonin group(MT)-12 rats in each.The morphological changes-ICAM-1 expression in intestinal mucosa tissue were observed-the villus height and mucosal thickness were measured-and the data were analyzed by computer analysis system respectively.Results The expression of ICAM-1 in OJ group was higher than that in SO group(P<0.01)-the architecture of intestinal tissue was impaired- besides both the villus height and mucosal thickness were reduced(P<0.01). The expression of ICAM-1 in MT group was lower than that in OJ group(P<0.01).The architectural distortion in the intestinal tissue was alleviated- an increase was noted in the villus height- same in mucosal thickness(P<0.01).Conclusion In Wistar rat model of obstructive jaundice-melatonin can down-regulate the expression of ICAM-1 and alleviate the archi-tectural distortion in the intestinal tissue.更多还原