【摘要】 目的:研究不同免疫抑制剂对肾移植患者精子运动功能的影响。方法:20例肾移植患者应用以普乐可复(FK506+霉酚酸酯+泼尼松)、17例应用环孢素(CsA+硫唑嘌呤+泼尼松)为主的免疫抑制治疗方案,15例正常男性为对照组。采用计算机辅助的精子分析系统分别检测精子活率、运动参数(前向运动百分率、直线速度VSL、曲线速度VCL、平均路径速度VAP)和精子形态。结果:3组精子活率[(81.7±5.7)%、(79.4±6.8)%、(83.8±6.0)%]、VCL[(24.1±8.6)%、(23.9±4.4)%、(24.8±4.2)%]和VAP[(19.7±6.6)%、(18.6±2.9)%、(21.0±4.0)%]差异均无显著性(P>0.05);FK506组的精子前向性运动百分率[(46.4±8.1)%]和VSL[(15.4±4.6)%]均显著高于CsA组[(33.3±6.4)%、(10.2±2.4)%],畸形率[(67.8±5.7)%]显著低于CsA组[(80.1±5.6%](P<0.05)。结论:FK506和霉酚酸酯的联合应用,有助于肾移植患者精子运动功能及形态的恢复。更多还原

【Abstract】 Objective: To study the effects of different immunodepressants on the sperm parameters of kidney transplant recipients. Methods: In 15 healthy fertile men and 37 kidney transplant recipients,ejaculates were aseptically obtained by masturbation.Thirty-seven patients were divided into two groups,20 patients were treated with Prograf(FK506) combination with mycophenolate mofetil(MMF) and prednisone;17 patients were treated with cyclosporine(CsA) combination with azathioprine with prednisone.The sperm viability,mobility parameters such as prorsad percentage motility,straight line velocity(VSL),curve line velocity(VCL),velocity of average path(VAP) and morph were estimated with a computer-assisted sperm analyzer(CASA) provided with a multiple-exposure photography system.Results: There were no significant difference in sperm viability rate [((81.7±5.7))%,((79.4)±6.8)% and((83.8)±(6.0))%],VCL[((24.1)±8.6)%、((23.9)±4.4)%、((24.8)±4.2)%] and VAP[((19.7)±6.6)%、((18.6)±2.9)%、((21.0)±4.0)%] among groups of FK506,CsA and control,respectively(P>(0.05)).The rate of anomaly [((67.8)±5.7)%],the prorsad percentage motility [((46.4)±8.1)%] and VSL [((15.4)±4.6)%] in the group of FK506 were respectively significantly lower and higher than those in the group of CsA [((80.1)±(5.6)%,((33.3)±6.4)%、((10.2)±2.4)%](P<(0.05)). Conclusion: The application of FK506 combined with MMF could help recover the mobility and morphology of the sperm in kidney transplantation recipients.更多还原