【摘要】 目的研究单药多烯紫杉醇每周方案及每3周方案治疗转移性乳腺癌的疗效与毒性。方法32例转移性乳腺癌患者,接受不同方案单药多烯紫杉醇的治疗,每周方案每次剂量范围为40~60mg,相当于20.4~28.7mg/m2,中位剂量为25mg/m2;3周方案剂量范围为每3周120~160mg,相当于70.9~86.1mg/m2,中位剂量为75mg/m2。评估多烯紫杉醇不同用药方案疗效与毒性的关系。结果单药多烯紫杉醇有效率为25.0%,对软组织疗效为60.0%,肝转移疗效为27.8%。分每周及每3周方案讨论。每周方案中,KPS评分≤70的患者多,曾用辅助治疗的较多,但疗效与3周方案相似,均为25.0%。每3周方案的Ⅲ~IV度白细胞毒性大,而每周方案白细胞毒性轻,耐受性良好。结论单药多烯紫杉醇治疗转移性乳腺癌疗效肯定。每周方案,对老年、一般状态差、部分难治性乳腺癌仍有疗效,且与每3周方案疗效相似。更多还原

【Abstract】 Objective To compare the efficacy and toxicity of docetaxel as a single agent for treating metastatic breast cancer with weekly and 3 weekly scheme.Methods Thirty-two patients with metastatic breast cancer received docetaxel as a single agent with different scheme.One with the dose ranging 40~60mg was given every week(20.4~28.7mg/m~2,median delivered dose intensity 25mg/m~2).The other group with the dose ranging 120~160mg given every three weeks(70.9~86.1mg/m~2,median delivered dose intensity 75mg/m~2).Efficacy and toxicity was evaluated.Results The response rate(RR) of docetaxel as a single agent was 25%,the RR of this drug in lung-metastatic and liver-metastatic patients were 60.0% and(27.8%),respectively.This drug was administered as either one-week or 3-week protocol.Although the efficacy was similar in these two protocol.The Ⅲ~IV grade of hematological toxicity was relatively high in later protocol.Toxicity was lower and tolerable in the one-week protocol.Conclusion Docetaxel is effective in treatment of metastatic breast cancer,when used as one-week protocol,it has certain degree of efficacy in the elderly and those who are refractory or whose performance status are poor,as does the three-week protocol.更多还原