【摘要】 目的:探讨胰岛素样生长因子-I受体与血管瘤发生发展的关系。方法:采用免疫组化SP法和半定量RT-PCR检测不同分期血管瘤中IGF-IR的表达水平,并与血管畸形及正常皮肤进行比较。结果:SP法和半定量RT-PCR结果均显示增殖期血管瘤内皮细胞IGF-IR表达水平增高,与血管畸形及正常皮肤组织间差异显著;而消退期的IGF-IR表达水平降低与血管畸形及正常皮肤相比,差异无显著性。结论:IGF-IR与血管瘤的发生发展有密切关系,为寻找皮肤血管瘤的诊断与治疗的新靶点提供了新的思路。更多还原

【Abstract】 Objective: To study the relationship between insulin-like grouth factor-I receptor (IGF-IR) and the progress of hemangioma. Methods: The expression of IGF-IR in the different stages of hemangiomas was measured using SP immunohistochemical method and RT-PCR,compared with vascular malformation and normal skin tissues. Results: The results of both SP immunohistochemical method and RT-PCR showed that the expression of IGF-IR in the proliferative stage of hemangioma was much higher than that in vascular malformation and normal skin tissues. The expression of IGF-IR in the resolving stage of hemangioma was decreased to a similar level to vascular malformation and normal skin tissues. Conclusion: There is significantly positive correlation between the expression of IGF-IR and proliferative degree of hemangioma, which may provide a new train of thought for finding the target to diagnose and treat hemangiomas.更多还原