【摘要】 目的:探讨高脂血症中医辨证分型与过氧化脂质(LPO)、超氧化物歧化酶(SOD)的相关性。方法:172例高脂血症患者分为痰浊阻遏型、脾肾阳虚型、肝肾阴虚型、阴虚阳亢型、气滞血瘀型。检测LPO、SOD,将5组证型的各项指标进行组间对照分析。结果:各证型的LPO均高于正常范围,其中以脾肾阳虚型最高,其他依次为肝肾阴虚、气滞血瘀、阴虚阳亢、痰浊阻遏,各证型的SOD均低于正常范围,以肝肾阴虚型最低,其他4型由低到高依次为阴虚阳亢、痰浊阻遏、脾肾阳虚、气滞血瘀。LPO脾肾阳虚与其他4型比较,有显著性差异(P<0.05);SOD,肝肾阴虚与其他4型有显著差异(P<0.05),气滞血瘀型与阴虚阳亢、痰浊阻遏、脾肾阳虚有显著差异(P<0.05)。结论:LPO、SOD可以考虑作为中医辨证分型客观化的现代化检测指标。更多还原

【Abstract】 Objective:The paper systematically reviews and analyzes causes,pathological changes of hyperlipemia,and research progress of LPO and SOD according to principle of determination of treatment based on the differentiation of symptoms and modern medcine.Then to study the relativity between hyperlipemia types based on syndrome differentiation in TCM and LPO,SOD.Method:①To differentiate the syndromes of 172cases with hyperlipemia in hospital and to divide them into five groups:phlegmstagnation-syndrome,spleen-kidney-yang-deficiency-syndrome,liver-kidney-yin-deficiency-syndrome,yin-dificiency-yang-supfluity-syndrome,qi and blood-stagnation-syndrome.②To carry out examinations of eight indices on LPO,SOD,we analyze and compare with five groups to find out their relativity.Result:In the phlegm-stagnation-syndrome group,LPO have relativity with TC(P<0.01),SOD have negative relativity with TC(P<0.05).In the spleen-kidney-yang-deficienty-syndrome group,LPO have relativity with LDL-C(P<0.05),SOD have relativity with HDL-C(P<0.01).In the qi and blood-stagnation-syndrome,LPO and SOD have relativity with LDL-C(P<0.05,P<0.01).This indicates that there exists certain relativity between hyperlipemia types based on syndrome differentiation in TCM and LPO,SOD.Conclusion:LPO and SOD can be one of testing indices in the objection of syndrome classification in TCM.更多还原