【摘要】 目的:探讨氯沙坦和缬沙坦对老年高血压患者的血压、血尿酸及尿α1-微球蛋白(α1-MG)的影响。方法:老年高血压患者60例,随机分为氯沙坦组和缬沙坦组,每组30例,分别服用氯沙坦50 mg/d及缬沙坦80 mg/d,若2周后血压未达到目标血压,即各增加剂量至100 mg/d和160 mg/d。于治疗前、后分别测量坐位血压以及血尿酸与尿α1-MG水平的变化。结果:两组治疗后收缩压及舒张压均较治疗前明显下降(P<0.01);缬沙坦组治疗后尿α1-MG水平较治疗前明显下降(P<0.01),血尿酸浓度无明显变化(P>0.05);氯沙坦组治疗后尿α1-MG水平及血尿酸浓度较治疗前均明显下降(P<0.01)。结论:氯沙坦和缬沙均能有效控制老年高血压患者的血压,对肾功能均有保护作用,但对于伴高尿酸血症患者应首选氯沙坦。更多还原

【Abstract】 Objective:To investigate the effect of Losartan and Valsartan on blood pressure,uric acid(UA) and α1-microglobulin(α1-MG)in elderly hypertensive patients.Methods: Sixty elderly hypertensive patients were randomly divided into Losartan group(n=30) and Valsartan group(n=30).The sitting blood pressure,UA and α1-MG were measured before and after treatment.Results: After treatment,both systolic and diastolic blood pressures decreased significantly in two groups(P<0.01);α1-MG after treatment in two groups and UA in Losartan group decreased significantly(P<0.01);and level of UA in Valsartan group was not changed after treatment(P>0.05).Conclusion:Losartan and Valsartan can effectively control blood pressure of elderly hypertensive patients,and both drugs have renal function protection.Losartan should be used in elderly hypertensive patients with hyperuricacidemia.更多还原