【摘要】 目的:了解322例荨麻疹患者的致病因素及各种因素之间的相互关系,比较2种氯雷他定治疗84例慢性特发性荨麻疹患者的疗效。方法:采用德国“敏筛”定量过敏原检测系统对322例荨麻疹患者进行了特异性IgE及过敏原的检测和分析,应用2种氯雷他定片治疗84例慢性特发性荨麻疹患者,并进行疗效对比和随访观察。结果:322例患者中有159例至少对1项过敏原阳性,阳性率为49.4%。平均阳性过敏原为(1.36±1.70)项;78例患者血清特异性总IgE阳性,阳性率为24.2%。2种氯雷他定片治疗前后患者症状和体征评分指数下降差异无统计学意义。治疗后,治疗组基愈率为37.2%,有效率为72.2%;对照组基愈率为39.0%,有效率为78.0%,两组疗效比较差异无统计学意义。结论:德国“敏筛”定量过敏原检测系统能较简便地检测特异性IgE和过敏原;国产氯雷他定治疗慢性特发性荨麻疹安全有效。更多还原

【Abstract】 Objective:To investigate the pathogenesis of urticaria and efficacy of loratadine in treatment of 84 chronic idiopathic urticaria patients.Methods:Using Allergy Screen Automatic allergy screening system,serum specific IgE and allergen were analyzed in 322 urticaria patients.Furthermore,the efficacy of loratadine in treatment of 84 chronic idiopathic urticaria patients was evaluated.Results:At least 1 allergen was positive in 159 of 322 urticaria patients.The positive rate was 49.4% and the average was 1.36±1.70.Serum specific total IgE was positive in 78 of 322 urticaria patients(24.2%).Symptom and sign scoring were evaluated before and after the treatment.There was no significant difference between 2 and 4 week course of treatment in the change of total symptom and sign scoring.The cure rate and effective rate were 37.2% and 72.2% in treatment group while 39.0% and 78.0% in controls respectively.There was no significant difference between the two groups.The recurrent rate was very low.Conclusions:The Germany Allergy Screen Automatic allergy screening system is a convenient tool to quantitatively detect allergen and specific IgE.Domestic-made loratadine is effective and safe in treatment of chronic idiopathic urticaria.更多还原