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曲唑酮与阿米替林治疗抑郁症对照研究

Controlled study of trazodone and amitriptylin in treatment of depression

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【作者】 杨建章郭振宇宋丽

【Author】 YANG Jian-zhang,GUO Zhen-yu,SONG Li.Zhumadian Mental Hospital of Henan Province,Zhumadian 463000,China

【机构】 河南驻马店市精神病医院河南驻马店市精神病医院 463000463000

【摘要】 目的:探讨曲唑酮对抑郁症的疗效。方法:将80例患者随机平分为两组,分别给予曲唑酮和阿米替林治疗,疗程4周。用汉密尔顿抑郁量表(HAMD)和副反应量表(TESS)评定疗效和不良反应。结果:治疗4周后,两药对抑郁症均有良好疗效,疗效近似(P>0.05);但曲唑酮不良反应小,程度轻(P<0.05或P<0.01)。结论:曲唑酮治疗抑郁症安全,疗效确切。

【Abstract】 Objective:To explore the efficacy of trazodone in the treatment of depression.Method:80 depressive patients were randomly divided into two groups.40 patients were treated with trazodone and others were treated with amitriptylin for 4 weeks.The therapeutic response and side effects were evaluated with the HAMD and TESS.Results:Trazodone and amitriptylin showed good effect in the treatment of depression,trazodone had similar efficacy to amitriptylin,and there were not significant difference between the two groups(P>0.05);but side effects of trazodone were less and milder(P<0.05 or P<0.01).Conclusion:Trazodone is a safe,reliable effect in the treatment of depression.

【关键词】 抑郁症曲唑酮阿米替林
【Key words】 depressiontrazodoneamitriptylin
  • 【文献出处】 临床精神医学杂志 ,Journal of Clinical Psychiatry , 编辑部邮箱 ,2006年02期
  • 【分类号】R749.4
  • 【被引频次】4
  • 【下载频次】43
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