【摘要】 目的研究2型糖尿病(T2DM)患者高敏C反应蛋白(hsCRP)与颈动脉内膜中层厚度(IMT)的关系。方法选取62例T2DM患者和30例正常对照者,用免疫透射比浊法测定hsCRP及用高分辨彩色多普勒测定颈动脉IMT,根据所测的hsCRP水平将T2DM患者分为低hsCRP组(0.05~3 mg/L)30例,高hsCRP组(>3~10 mg/L)32例;T2DM患者给予降糖、调脂等综合性治疗1年,再测定治疗后hsCRP和颈动脉IMT,分析hsCRP与颈动脉IMT变化的关系。结果T2DM患者综合治疗1年后,高hsCRP组颈动脉IMT的增厚明显高于低hsCRP组[(1.05±0.15)mm vs(0.84±0.12)mm(P<0.05)];相关分析中,T2DM患者高hsCRP组在治疗前、后颈动脉IMT与hsCRP呈正相关(r=0.882,r=0.905,均P<0.05)。结论在T2DM中,hsCRP水平的增高与颈动脉IMT的增厚有关,提示血清hsCRP增高可能是T2DM患者合并早期动脉粥样硬化的危险因素之一。更多还原

【Abstract】 Objective To investigate the relationship of serum high sensitivity C-reactive protein(hsCRP) to intima-media thickness(IMT) of the carotid artery in subjects with type 2 diabetes mellitus(T2DM).Methods Serum hsCRP level was measured by immunonephelometric assay and IMT of the carotid artery was determined by high-resolution ultrosonography in 62 diabetic and 30 normal subjects.According to the hsCRP level,the diabetic patients were divided into two subgroups: low hsCRP group(0.05-3 mg/L,30 cases) and high hsCRP group(>3-10 mg/L,32 cases).After a year’s comprehensive therapy,hsCRP and IMT of the carotid artery were examined again in the patients with T2DM.Results The IMT of carotid artery was significantly increased in high hsCRP group as compared with that in low hsCRP group(1.05±0.15) mm vs(0.84±0.12) mm(P<0.05) after a year′s treatment.Both before and after the therapy,serum hsCRP correlated positively with IMT of the carotid artery in the patients of high hsCRP group with T2DM(r=0.882,r=0.905,all P<0.05,respectively).Conclusion Elevated serum hsCRP may be one of probable risk factors in the early atherosclerosis in the patients with T2DM.更多还原