【摘要】 目的探讨高胆红素血症新生儿血清神经元特异性烯醇化酶(NSE)和新生儿行为神经测定(NBNA)的变化、两者的相关性及其临床意义。方法应用酶联免疫吸附法检测42例高胆红素血症新生儿和29例正常新生儿血清中NSE浓度,同步测定血清总胆红素(TSB)、白蛋白含量,计算胆红素-白蛋白比值(B/A),并行新生儿NBNA评分。高胆组按TSB≥342μmol/L和171～342μmol/L分为实验组a和实验组b,对照组TSB<85.5μmol/L,结果两实验组血清NSE浓度均较对照组显著升高(P<0.01),两实验组间NSE浓度差异无显著性(P>0.05)。两实验组NBNA评分值均明显低于对照组(P<0.01),两实验组间差异无显著性(P>0.05)。血清NSE浓度与NBNA评分均呈显著性负相关(P<0.01)。结论血清NSE测定比TSB、B/A值能更早期预测新生儿胆红素脑损伤患病风险。更多还原

【Abstract】 Objectives To explore the potential role of serum levels of neuron specific enolase (NSE) in full-termnewborns with hyperbilirubinemia. Methods Serum levels of NSE by ELISA method,total serum bilirubin (TSB),albumin and bilirubin/ albumin (B/A) ratio were detected in 42 full-term newborn infants with hyperbilirubinemia and 29 normalfull-term newborn infants,respectively. The level of TSB ≥ 342μmol/L were defined as group A (31 cases),171-342 μmol/L as group B (29 cases),and 29 normal newborn infants whose TSB level less than 85.5 μmol/L were as group C (29 cases). Neonatal behavioral neurological assessment (NBNA) was undertaken in all three groups on the same day after blood sampling and on the 28 days old,respectively. Results (1) Serum levels of NSE in groups A and B were significantly higher than that in group C,while no significant difference in serum level of NSE was observed between group A and group B. (2) The mean NBNA score in groups A and B were significantly lower than that in group C,and also no significant difference was found between group A and group B. (3) Serum NSE levels were inversely correlated to NBNA score. Conclusions Comparing to serum TSB and B/A,serum NSE can be more helpful for predicting bilirubin-related early brain damage in term newborn infants with hyperbilirubinemia.更多还原