【摘要】 目的:探讨高效液相色谱法(HPLC)测定酮洛芬凝胶剂的含量。方法:采用A g ilen t C 18色谱柱(200mm×4.6mm,5μm),以磷酸二氢钾溶液-乙腈(50:50)为流动相,流速为1.0m l.m i-n 1,检测波长为255nm。结果:酮洛芬在3.9984~23.9904μg.m-l 1范围内,线性关系良好;平均回收率为99.35%,RSD=0.75%(n=6)。结论:该方法结果准确,精密度和重现性好,可用于酮洛芬凝胶剂的质量控制。更多还原

【Abstract】 Objective:To determine Ketoprofen gel by HPLC.Methods:Agilent C18（200mm×4.6mm,5μm）column was used with the mobile phase of 0.01mol·L^-1KH₂PO₄（pH3.5）-acetonitrile（50:50）,a flow rate of 1.0ml·min^-1 and a detection wave of 255nm.Results:There was a good linear relation within the range of（3.9984～23.9904）μg·ml^-1.The average recovery and relative standard deviation of the method were 99.35% and 0.75%（n=6）,respectively.Conclusion:The method is accurate,precise and reproductive for the quality control of Ketoprofen gel.更多还原