【摘要】 目的评价多西环素缓释给药系统(SRDDS)移植于引导组织再生(GTR)屏障膜下的骨缺损中时,对口腔细菌定植屏障膜的影响。方法10例各有一对可比较骨缺损的患者,其中一侧缺损移植SRDDS并在表面覆盖ePTFE屏障膜(试验组),对照侧仅在缺损表面覆盖ePTFE膜(对照组)。术后4～5周取出屏障膜作扫描电镜(SEM)观察。结果SEM观察结果表明不管是否局部应用SRDDS,屏障膜所有暴露于口腔的部分均被细菌严重定植,而根尖部分的显微区细菌定植阴性。在膜中部,试验组屏障膜上的显微区细菌定植阳性百分率(31.67%)低于对照组(61.67%),且菌落构成简单。结论当此缓释系统结合GTR治疗牙周骨缺损时,能有效减少细菌定植于屏障膜向牙面的中部,从而有可能提高GTR治疗的临床效果。更多还原

【Abstract】 Objective To evaluate the effects of a novel local sustained-release drug delivery system (SRDDS) for doxycycline on bacterial colonization of the barrier membranes when it is implanted into osseous defect treated by guided tissue regeneration (GTR). Methods 10 patients, each with one pair of bilateral and comparable periodontal bone defects, had the test defects and were treated with GTR plus SRDDS graft, while the control defects were treated with GTR alone. The barrier membranes were harvested by reentry surgery for SEM analysis after 4～5 weeks. Results The SEM analyses revealed that all exposed portions of membranes were heavily colonized bacteria and no microscopic field was positive for bacterial colonization on the apical portions of the membranes, regardleless of local application of SRDDS. But on the mid-portion of the membranes, significantly fewer microscopic fields were positive for bacterial colonization on test group than that on control group (31.67% vs. 61.67%). The floral composition on the mid-portion of the test membranes was simpler than that on the control membranes.Conclusion The SRDDS used in this study could effectively reduce bacterial colonization of the mid-portion of tooth-facing surface of the barrier membranes, and may improve the predictability of GTR.更多还原