【摘要】 目的应用双功能彩色多普勒超声诊断仪检测儿童颈动脉内膜中膜厚度,找寻与临床前动脉粥样硬化发病相关的危险因素。方法选择5~17岁儿童79例,利用超声技术定量评价其颈动脉内膜中膜厚度及心脏结构和功能,应用日立7060型全自动生物化学分析仪检测其空腹血浆总胆固醇、甘油三酯、高密度脂蛋白及低密度脂蛋白含量,计算动脉粥样硬化指数。对其进行体格检查并测量身高、体重及血压,计算体质指数以反映身体肥胖程度;详细询问高血压、冠心病、肥胖及血脂紊乱家族史。通过Logistic回归分析进一步分析这些指标与颈动脉内膜中膜厚度的相关性。结果具有高血压、肥胖及血脂紊乱阳性家族史的儿童颈动脉内膜中膜厚度较阴性家族史儿童明显增厚(χ2=4.364,P<0.05);多元Logistic回归方程表明,颈动脉内膜中膜厚度与舒张压及动脉粥样硬化指数存在一定的定量关系。结论对于动脉粥样硬化高危儿童应定期B超监测颈动脉内膜中膜厚度,并针对相对危险因素予以预防。更多还原

【Abstract】 Aim To discuss carotid intimal-media thickness in children using B-mode ultrasound and look for the risk factors of pre-clinical atherosclerosis.MethodsCarotid intimal-media thickness was detected in seventy-nine children aged from 5 to 17 years old by using B-mode ultrasound.And cardiac structure and function were measured by color Doppler ultrasound.Total plasma cholesterol,triglyceride,high density lipoprotein-cholesterol and low density lipoprotein-cholesterol were detected by HITACHI 7600 automatic biochemical analyzer.Atherogenic index was calculated as LDLC/HDLC.Physical examination was carried on.Blood pressure was measured.Body mass index was calculated according to body height and weight.Familial history of hypertension,coronary heart disease,obesity and dyslipidemia were investigated.The relationship between carotid intimal-media thickness and indexes above was analyzed by Logistic regression.ResultsThere was a difference between the measurements of carotid intimal-media thickness on children with positive and negative histories of obesity,dyslipidemia and hypertension(χ2=4.364,P<0.05).The multiple Logistic regression equation indicated that there were quantitative relationship between carotid intimal-media thickness and diastolic blood pressure and atherogenic index.ConclusionsCarotid intimal-media thickness monitoring should be carried on if children had high risk factors of atherosclerosis for better prevention and intervention.更多还原