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急性胰腺炎患者血清细胞因子和炎症介质的变化

Alteration of cytokines and inflammatory mediators in the serum of acute pancreatifis patient

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【作者】 白春洋宋艳敏雷素萍

【Author】 BAI Chun-yang~(1),SONG Yan-min~(2),LEI Su-ping~(1)(1.Huaihe Hospital of Henan University,KaiFeng 475000,(China;) 2.Seconed People′s Hospital of KaiFeng,KaiFeng 475000,China)

【机构】 河南大学淮河医院开封市第二人民医院河南大学淮河医院 河南开封475000河南开封475003河南开封475000

【摘要】 目的:探讨急性胰腺炎(AP)患者血清C反应蛋白(CRP)白介素-10(IL-10),肿瘤坏死因子-α(TNF-α),一氧化氮(NO)的临床意义。方法:分为三组,轻型AP(MAP)组,重型AP(SAP)组和对照组,同时测定上述指标。结果:①AP患者血清CRP、IL-10、TNF-α、水平均明显高于对照组(P<0.01),血清NO水平均明显低于正常对照组(P<0.01)。②SAP患者血清CRP,TNF-α,水平均明显高于MAP组(P<0.01)③MAP组患者血清IL-10、NO水平均明显高于SAP组(P<0.01)。结论:上述血清因子有助于AP的诊断和其病情严重程度的识别。

【Abstract】 Objective:To study the relations between serum levels of CRP,IL-10,TNF-α and NO in patients with acute pancreatitis(AP),and their clinical significance.Methods:Contained moderate acute pancreatitis(MAP),severe acute pancreatitis(SAP) and contrast group.Specimens were examined the serum levels of CRP,IL-10,TNF-α.Results:(1)The serum levels of CRP,IL-10,TNF-α in AP group were more than that in contrast group(P<0.01),the serum levels of ON in AP group were less than that in contrast group(P<0.01).(2)The serum levels of CRP,TNF-α,in SAP group were more than that in MAP((P<0.01)).(3)The serum levels of IL-10,NO in MAP group were more than that in SAP(P<0.01).Conclusions:The results show that all those levels have directive dinical singnificances to judge serious degrees of AP.

【关键词】 胰腺炎C反应蛋白白细胞介素10
【Key words】 pancreatitisc-reactive proteinIL-10
  • 【文献出处】 军医进修学院学报 ,Academic Journal of PLA Postgraduate Medical School , 编辑部邮箱 ,2006年02期
  • 【分类号】R576
  • 【被引频次】12
  • 【下载频次】123
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