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MALDI-TOF质谱技术研究胰岛素海藻酸钠纳米粒特性
Studies on characteristics of sodium alginate nanoparticles of the insulin by MALDI-TOF mass spectrometry
【摘要】 从海洋生物中提取海藻酸纳和壳聚糖作为纳米粒的包被材料,并分别包装成人胰岛素纳米粒。选用基质辅助激光解吸离子化飞行时间(Matrix-assistedlaserdesorptionionization/timeofflight,MALDI-TOF)质谱技术研究胰岛素海藻酸钠纳米粒包装、释放过程及在不同酸碱介质条件下的稳定性。
【Abstract】 Sodium alginate and chitosan extracted from the halobios were selected as packaging materials of nanoparticles of the human insulin nanoparticles, respectively. Matrix-assisted laser desorption ionization /time of flight (MALDI-TOF) mass spectrometry was used to study the processes of packaging and releasing of the insulin and its stability in the different basic and acidic mediums from the sodium alginate nanoparticles .
【关键词】 MALDI-TOF;
质谱;
胰岛素;
纳米粒包装;
稳定性;
【Key words】 MALDI-TOF; mass spectrometry; insulin; nanoparticle; stability;
【Key words】 MALDI-TOF; mass spectrometry; insulin; nanoparticle; stability;
【基金】 国家自然科学基金资助项目(0402760633);福建省自然科学基金资助项目(C0310006)
- 【文献出处】 海洋科学 ,Marine Sciences , 编辑部邮箱 ,2006年01期
- 【分类号】R318.08
- 【被引频次】2
- 【下载频次】265