【摘要】 目的探讨特发性肺纤维化(IPF)的螺旋CT表现及与组织病理的相关性。方法回顾性分析我院自1998年5月～2005年5月收治10例经病理检查确诊为IPF患者的CT影像资料,并评价其CT征象与组织病理的相关性。结果①磨玻璃样密度影2例,优势地分布于肺的周边部,病理为间质性肺泡壁炎。病程多在一年以下。②小叶间隔增厚7例,小叶间质内增厚6例,支气管血管束增粗5例,病理为小叶内细支气管血管周围间质及肺泡间隔增厚。病程多在2～3年。③蜂窝肺4例,分布于肺的周边部,其病理为肺腺泡固有结构破坏。病程多在3年以上。结论IPF的螺旋CT表现反应其不同病程的病理变化,对IPF的诊断及判断其进展和预后具有重要意义。更多还原

【Abstract】 Objective To evaluate the correlation between the CT morphologic features and histopathology findings of idiopathic pulmonary fibrosis(IPF). Methods The imaging data of 10 patients with IPF confirmed by pathology in our hospital were analyzed retrospectively, and the correlation of CT features and histopathology findings was studied. Results Helical CT scanning was performed on 10 patients. Of 10 cases, two had ground梘 lass opacity that predominantly distributed in the peripheral. Pathology showed the inflammation of interstitial pulmonary alveoli walls. The course of disease was less than one year.The intralobular interstitial thickening was found in 6, the interlobular sepatal thickening in 7 and the thickened bronchovascular bundle in 5. Interstitial and pulmonary alveoli gaps became thicker around blood vessels of interlobular bronchiole. The course ranged from 2 to 3 years. Four had honeycomb appearance that predominantly distributed in peripheral zone of lung. The damage to the structure of pulmonary acinus which dilated and merged into honeycomb state was found under the micrscope. The course was more than 3 years. Conclusion CT can provide the significant information for the assessment of the pathologic severity of IPF. It is useful for the diagnosis of IPF.更多还原