【摘要】 目的:观察石斛合剂对衰老糖尿病大鼠血清胰高血糖样肽-1(GLP-1)水平的影响,探讨其治疗衰老糖尿病的可能机制。方法:采用D-半乳糖致衰老,继而加高脂高糖及腹腔注射链脲佐菌素(STZ)制备大鼠衰老糖尿病模型,后测定大鼠血清中SOD、MDA、GLP-1浓度。结果:石斛合剂各治疗组与衰老及衰老糖尿病模型组相比,大鼠血清中MDA浓度明显降低(P<0.05),而SOD和GLP-1水平都有显著升高(P<0.05￣0.01)。结论:石斛合剂可显著升高衰老及衰老糖尿病模型大鼠SOD水平,降低MDA水平,促进GLP-1分泌。其作用机制可能是与其通过促进GLP-1分泌进而促进胰岛细胞增殖有关。更多还原

【Abstract】 Objective: To study the influence of Dendrobium Compound (DC) on GLP-1 in aged diabetic rats, and to investigate the possible mechanism of DC on the aged diabetes. Methods: The aged diabetic rats were induced by D-galactose, followed by enrich-diet and injecting streptozotocin (30 mg/kg) , and their serum concentrations of SOD?MDA and GLP-1 were measured . Results: Compared to the aged group and the aged diabetic group, MDA in each DC treatment group significantly declined. (P<0.05), but SOD and GLP-1 markedly ascended. Conclusion: DC can decrease the blood glucose and MDA, evidently raise SOD and GLP-1 levels of the aged rats and the aged diabetic rats. One of DC treatment mechanisms is associated with its enhanced the islet cell proliferation by increasing the incretion of GLP-1.更多还原