【摘要】 以D-酒石酸与正庚醇为原料,在对甲苯磺酸催化下合成了手性拆分剂D-酒石酸正庚酯,通过正交实验确定优化反应条件为:D-酒石酸100 mmol,n(D-酒石酸)∶n(正庚醇)=1.0∶2.6,对甲苯磺酸0.5 g,甲苯50mL,回流反应约1 h,酯化率99%,收率在93%以上。其结构经IR确证。更多还原

【Abstract】 A chiral resolving reagent,n-heptyl D-tartrate,was synthsized from D-tartaric acid and n-heptanol using p-toluene sulfonic acid as a catalyst by refluxing for 1 h.The effect of molar ratio of(reactant,) amount of solvent and catalyst and stir speed on the yield were discussed by orthogonal test.The optimum reaction conditions were as fillows: the molar ratio of D-tartaric acid to n-heptanol was 1.0 ∶(2.6,) the amount of p-toluene sulfonic acid was 0.5 g,and toluene was 50 mL.The yield was(about) 93% and the esterification rate was over 99% under the optimum reaction conditions.The structure was confirmed by IR.更多还原