【摘要】 目的研究endoglin(CD105)标记的微血管密度(microvesessel density,MVD)及血管内皮生长因子(vascular endothelial growth factor,VEGF)在子宫内膜癌、子宫内膜复杂性增生及正常子宫内膜的表达,探讨CD105-MVD及VEGF值与临床病理参数的关系。方法采用免疫组化法检测了25例子宫内膜癌、10例复杂性增生、8例正常增生期内膜中CD105和VEGF的表达,计数MVD值,用CD105-MVD与临床参数进行分析。结果子宫内膜癌、复杂性增生及正常内膜CD105-MVD值依次为28.680±5.808、28.467±5.242、12.667±2.575。内膜癌、复杂性增生组显著高于正常组,CD105-MVD值与临床分期、浸润肌层深度及局部淋巴结转移有关;VEGF在内膜癌组的阳性表达率(80%),显著高于复杂增生组(30%)和正常组(20%),VEGF与临床参数无关,CD105与VEGF具有显著相关性。结论CD105是影响子宫内膜癌发生与发展的重要因素,可能与患者的预后有关。更多还原

【Abstract】 ObjectiveTo study the expression of endoglin(CD105) and vascular endothelial growth factor(VEGF) in endometrial carcinoma(EC),complex endometrial hyperplasia(CH) and normal proliferative endometrium.To investigate the relationship between CD105-MVD(microvesessel density),VEGF and the clinicopathologic factors.MethodsThe expression of CD105 and VEGF in endometrium was detected with immunohistochemistry in 25 cases of EC,10 cases of CH and 8 cases of normal proliferative endometrium.The MVD value was counted.The relation ship between CD105-MVD and the clinicopathologic factors was analyzed.ResultsThe CD105-MVD value in EC,CH and normal endometrium was(28.680)±(5.808)、(28.467)±(5.242) and(12.667)±(2.575) respectively.The CD105-MVD value of EC group and CH group was significantly higher than that of normal endometrium.CD105-MVD was significantly correlated with the clinical stage,depth of infiltrating muscular layer and the focal lymph node metastasis.The VEGF positive expression rate(80%) in EC group was significantly higher than that in CH group(30%) and normal group(20%).VEGF was not correlated with the clinicopathologic factors.VEGF was significantly correclated with the CD105-MVD.ConclusionCD105 is an important factor which influences the development of the EC and probably related with the prognosis of EC.更多还原