【摘要】 选择丙酮为起始原料,与甲酸乙酯进行缩合反应得到第一步反应产物甲酰丙酮;再与乙酰乙酸乙酯缩合合成目标化合物2-羟基-4-甲基苯甲酸.将终产物通过红外光谱、质谱、核磁共振进行检测,综合分析各波谱的检测结果,并与标准图谱进行比较,确定所合成产物为2-羟基-4-甲基苯甲酸.在产物的分离纯化上用pH梯度分离法,简化了合成工艺,得到了较高的产率.更多还原

【Abstract】 In order to study the synthesis method of 2-hydroxy-4-methyl benzoic acid,this experiment adopts acetone and ethyl formate to synthesize formyl acetone.2-hydroxy-4-methyl benzoic acid has been synthesized by formyl acetone and acetoacetic ester.The structure of the ultimate product has been identified by three ways including IR,MS and ¹HNMR.The best synthetic condition has been chosen by repeated test,and because introducing pH gradient separation the synthetic route has been simplified.更多还原