【摘要】 目的:了解小巨核细胞免疫组化染色(APAAP法)在外周血细胞减少症鉴别诊断中的意义。方法:凡外周血细胞一系(主要指单纯血小板减少)、二系或全血细胞细胞减少者均列为研究对象。用小巨核细胞免疫组化染色(APAAP法)患者骨髓涂片,光镜下计数巨核细胞并进行分类。结果:小巨核细胞分别见于11例骨髓增生异常综合症(MDS)及5特发性血小板减少性紫癜(ITP);而8例再生障碍性贫血(AA)未见巨核细胞。淋巴样小巨核细胞仅见于MDS。结论:用小巨核细胞免疫组化染色(APAAP法)检查骨髓涂片中的小巨核细胞有助于外周血细胞减少症的鉴别诊断。更多还原

【Abstract】 Objective: To study the role of micromegakaryocyte immunohistochemical staining (APAAP) in bone marrow smears of patients with peripheral cytopenia. Method: Patients with one or two lineage cytopenia or pancy-topenia were allowed into the study. Bone marrow smears of patients were stained by microhistochemical APAAP. Micromegakaryocytes were counted under light microscopy. Results: Micromegekaryocytes were detected in 11 patients with myelodyslplastic anemia (MDS) and in 5 patients with idiopathic thrombocytopenia (ITP). Micromegekaryocytes were not detected in 8 patients with aplastic anemias (AA). Lymphocytoid micromegakaryo-cytes were only detected in patients with MDS. Conclusion: It is suggested that detection of micromegekaryocyte with immunohistochemical staining (APAAP) might be useful in differentiation diagnosis of one or two lineage cytopenia or pancytopenia.更多还原