【摘要】 血管生成素(Ang)家族是一类促血管生成因子,参与生理性及病理性的血管生成。糖尿病时,视网膜局部Ang表达发生变化。Ang-1可参与血管生成,维持血管稳定,抑制视网膜内皮细胞凋亡、炎症、渗出及白细胞黏附;Ang-2可促进血管出芽,导致周细胞丧失,增加血管通透性。Ang可能通过上述机制参与了糖尿病视网膜病变的发生、发展。更多还原

【Abstract】 The angiopoietin(Ang) family is a series of angiogenic factors,participating in the physiological and pathological vasculogenesis.The expression of angiopoietins alters in diabetic retina.Ang-1 is essential for vascular angiogenesis.It can sustain vascular stabilization,inhibit retina endothelial cells apoptosis,inflammation,leakage and leukocytes adhension.Ang2 can promote vascular sprouting,induce pericytes loss,increase vascular permeability.Ang may play a role in the pathogenesis and development of diabetic retinopathy via the mechanisms mentioned above.更多还原