【摘要】 目的:应用多焦视网膜电图评价在中心性渗出性脉络膜病变患者光动力疗法治疗后视网膜功能的改变。方法:对11例(11眼)中心性渗出性脉络膜病变患者PDT在治疗前及治疗后7d～3mo分别查视力、多焦视网膜电图(mfERG)、眼底荧光造影、光学相干断层扫描图(OCT)。应用重复测量方差分析比较mfERGN1、P1波振幅密度变化。结果:中心性渗出性脉络膜病变患者PDT治疗后7d时的mfERG1～6环N1波、P1波振幅密度与治疗前比较均无明显差异(P>0.05),在治疗后45d时mfERG1～5环N1、P1波振幅密度值与治疗前有显著提高(P<0.05),治疗后3mo时mfERG1～5环N1波、1～4环P1波振幅密度值与治疗前有显著提高(P<0.05)。结论:PDT治疗中心性渗出性脉络膜病变患者疗效显著。PDT疗法可以提高或稳定中心性渗出性脉络膜病变患眼视力,mfERG显示它还能改善黄斑部的功能。更多还原

【Abstract】 AIM:To assess the retinal function of patients with central exudative chorioretinopathy (CEC) after photody- namic therapy (PDT) with multifocal electrore- tinogram (mfERG). · METHODS: Eleven patients (11 eyes) with CEC detected with visual acuity, multifocal electroretinography (MF-ERG) ,optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) before and 7d-3mo later after PDT, the changes of mfERG N1 and P1 wave peak amplitude densities were analyzed with repeated measurement analysis of variance. · RESULTS: N1 and P1 wave peak amplitudes densities in the ring 1-6 of patients with CEC did not change significantly at 7d after treatment (P<0.05). N1 and P1 wave peak amplitudes densities improved in ring 1-5 at 45d after treatment (P<0.05). The wave peak amplitudes densities of N1 wave in ring 1-5 and P1 wave in ring 1-4 improved after treatment 3mo. (P<0.05). · CONCLUSION: The therapeutic effect of PDT on CEC was significant. PDT can improve or stabilize visual acuity of the eye with CEC, and mf-ERG reveals that the macular function can be improved.更多还原