【摘要】 目的:比较正常人和原发性青光眼患者不同分区的多焦视觉诱发电位(multifocalvisualevokedpoten-tial,mfVEP),评价mfVEP在青光眼诊断中的作用。方法:采用法国VisionMonitor多焦视觉电生理仪的二阶kernel技术检测21例32只正常对照眼、37例58只原发性青光眼的mfVEP,将青光眼mfVEP振幅均方根(rootmeansquare,RMS)及潜伏期与正常对照眼行不同分区的比较。结果:正常眼mfVEP的RMS值个体间变异大(变异系数CV=43.05%)。青光眼mfVEP的RMS值在上下半视野,鼻上、颞上、鼻下、颞下四个象限及各个环形分区均较正常对照眼小,且在0～10°环形区域及鼻上象限差异有显著性意义(P<0.05),二者各个区域的潜伏期无差异。结论:正常人mfVEP个体间变异性大;青光眼患者mfVEP振幅较正常人下降,且在中央区域及鼻上象限更为显著。更多还原

【Abstract】 AIM: To test the ability of multifocal visual evoked potential (mfVEP) in the detecting of glaucoma by comparing the mfVEP recorded from normal subjects and glaucoma patients. METHODS: The mfVEP of 32 normal eyes (n =21) and of 58 eyes (n =37) with primary glaucoma were recorded with the Vision Monitor electrophysical apparatus by the second kernel analysis and to determine the correlation of the topographic location between them. RESULTS: There were significant variability (the coefficient of variation was 43.05%) in mfVEP RMS amplitude in the normal subjects; The RMS amplitude of eyes with glaucoma were smaller than that of the normal eyes and significantly statistical difference were found in the relatively center (namely the 0°-10° ring zone) and in superior nasal quadrant (P <0.05) while there were no significantly statistical differences of the latency time between them. CONCLUSION: The normal subjects have large individual variability of mfVEP responses. The RMS amplitude of the mfVEP of glaucomatous eyes descends, especially in center zone and superior nasal quadrant.更多还原