【摘要】 目的观察脑出血患者发病后2周内血清肿瘤坏死因子-α(TNF-α)含量的变化及其与C-反应蛋白(CRP)的相关性。方法用放射免疫法测定高血压脑出血患者发病后24h、7d、14d血清TNF-α,用免疫比浊法测定CRP含量,并进行相关性分析。结果患者血清TNF-α及CRP均在发病后24h升高,TNF-α7d时达高峰,14d时又下降,但仍高于对照组;急性期TNF-α含量和CRP与出血量及血肿周围水肿区体积呈正相关。结论CRP、TNF-α参与了脑出血的病理生理过程,出血量及血肿周围水肿区体积越大,TNF-α和CRP的含量越高,两者可作为神经元损伤定量生化指标的标记物,也可作为监测病情变化和药物疗效评价的指标。更多还原

【Abstract】 Objective To observe the dynamic changes of tumor necrosis factor alpha(TNF-α)in blood of patients with intracerebral hamorrhage(ICH)in 2 weeks after onset,and to evaluate its relation with C-reactive protein.Methods TNF-α content in blood was measured by radio-immunoassay method at different time after ICH onset(the first 24 hour,7th day,14th day).C-reactive protein was measured by turbidmetry immunoassay.Results The TNF-α and CRP in ICH group were significantly higher than those in control group(P<0.001).They increased within the first 24 hour after ICH onset,TNF-α reached climax at the 7th day,and decreased obviously at the 14th day;its content is positively related to CRP and the volume of hemorrhage and edema(P<0.01).Conclusion TNF-α and CRP participate in the pathophysiological process of brain damage after ICH.The larger the volume of hemorrhage and edema was,the higher the content of TNF-α in blood.Therefore,they may serve as quantitative biochemical markers of neuron damage when stroke occures,the index of monitoring state of patients with stroke and the index of evaluateing curative effect of drug.In patients of ICH,sodium aescinate may have neuroprotective action and improve prognosis which may depend on decreasing the synthesis and/or release of TNF-α.更多还原