【摘要】 用3-(3-苯基-3-羟基丙基)斯德酮和芳香醛反应合成了cis-和trans-4,6,7,8-四氢-4,6-二芳基氧杂吖庚因[4,3-c]斯德酮,这两种异构体在通常情况下都是稳定的,可以用柱层析进行分离提纯.在质子酸催化下,两种异构体均可以发生异构化,得到cis-和trans-异构体混合物.顺反式异构体的比例可以用1H NMR进行测定.更多还原

【Abstract】 Both cis-and trans-4,6-diaryl-4,6,7,8-tetrahydro[1,4] oxazepino[4,3-c]sydnones prepared from the reaction of 3-(3-phenyl-3-hydroxylpropyl)sydnone and aromatic aldehydes are stable isomers and can be isolated and purified by chromatography commonly.In the presence of protonic acid,cis-or trans-isomer can be isomerized to a mixture of cis-and trans-isomer.The chemical shift of(H-4) of cis-isomer is smaller than that of trans-isomer.The ratio of cis-and trans-isomer can be measured by ~1H NMR.更多还原