【摘要】 目的:观察三环类抗抑郁药阿米替林、去甲肾上腺素再摄取抑制剂马普替林、选择性5-羟色胺再摄取抑制剂氟西汀和舍曲林的定量脑电图变化特征。方法:选择经DSM-IV诊断标准诊断的80名重度抑郁发作患者随机分为阿米替林、马普替林、氟西汀和舍曲林四个药物组,在治疗前、首次给最小剂量抗抑郁药9小时后、治疗1周后和治疗4周后进行脑电图的测定,并在治疗前进行Ham ilton抑郁量表的测定。结果:抗抑郁药对脑电功率的影响主要在给药早期。结论:四种抗抑郁药在α频段和β频段具有不相同的脑电图特征。更多还原

【Abstract】 Objective: To differentiate the quantitative EEG(qEEG) changes caused by three categories of antidepressants,i.e.Amitriptyline(TCA),Maprotiline(NRI) and Sertraline and Fluoxetine(SSRI).Methods: Eighty patients with DSM-Ⅳ major depression were singled out and randomly divided into four treatment groups with Amitriptyline,Maprotiline,Sertraline and Fluoxetine.EEG’ s was recorded respectively at the baseline,nine hours after single dose was administered,one week and four weeks after treatments.Hamilton Rating Scale for Depression was also rated at baseline.Results: The changes of antidepressants occurred nine hours after single dose.Conclusions: Antidepressants have different effects on EEG in alpha and beta frequency.更多还原