【摘要】 目的:探讨微卫星不稳定性(m icrosatellite instab ility,M I)与子宫颈癌的相关性。方法:22例子宫颈浸润性鳞癌石蜡标本,选取3、5和6号染色体上的3个微卫星位点D3S1289、D5S406、D6S277进行M I分析。结果:在子宫颈癌标本中3个位点均未发现M I和杂合性缺失(LOH)的改变。结论:3个微卫星位点未见M I和LOH的改变,可能与病例少、位点少、种族及取样有关。更多还原

【Abstract】 Objective:To investigate microsatellite instability(MI) in cervical cancer.Methods: MI of 3 microsatellite markers were detected in 22 invasive squamous cancers and self normal cervix.Results: MI and loss of heterozygosity(LOH) were not detected in D3S1289,D5S406,D6S2773 in 22 cervical cancers.Conclusions: The results of MI analysis were negative,may be related with less cases and microsatellite markers、races and clinician-collected cervical samples.更多还原