【摘要】 目的:观察中草药远志对雄性小鼠生殖细胞遗传物质损伤的防护作用。方法:采用雄性小鼠生殖细胞非程序DNA合成实验。结果:远志各剂量组诱导的非程序DNA合成与正常对照组比较差异无显著性(P> 0．5);1．0～4．0 g·kg-1剂量远志对醋酸铅所诱导的非程序DNA合成有明显抑制作用(P<0．01),并且随着远志浓度的增加,其抑制作用逐渐增强,超过一定剂量,其抑制作用不再增强。结论:远志对小鼠生殖细胞遗传物质具有保护作用。更多还原

【Abstract】 Objective To observe the preventive effect of Polygala tenyi folia willd on damage of genetic materials in male mouse reproductive cells. Methods Unscheduled DNA synthesis (UDS) test in male mouse reperoductive cells was used. Results There was no significant difference (P>0. 05) while UDS was induced by Polygala tenyi folia willd with various doses comparing with normal control. Nevertheless, Polygala tenyi folia willd in doses ranged from 1. 0 to 4. 0 g · kg-1 inhibited strikingly UDS induced by Pb (CH3COO)2 (P<0. 01), and the inhibitory effect was enhanced with the incresse of the concentration. However the effect did not change when the dose reached a certain concentration. Conclusion Polygala tenyi folia willd shows a protective effect, namely antimutagenesis, on injury of genetic materials in reproductive cells of male mouse.更多还原