【摘要】 目的对动力源保健酒的毒性和致突变性进行初步安全性评价。方法依照《保健食品安全性毒理学评价程序和检验方法规范》进行试验设计和检测。结果动力源保健酒10倍浓缩液对雌、雄小鼠经口半数致死量(LD50)均大于40.0g/kg bw,根据急性毒性半数致死量(LD50)毒性分级属实际无毒;Am es试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验结果均为阴性,未见致突变性;30d喂养试验,实验动物生长发育良好,血液学检查、生化学检查、主要脏器脏体比及组织学检查结果与对照组相比,差异均无显著性(P>0.05)。结论动力源保健酒作为食品是安全的。更多还原

【Abstract】 Objective In order to assess safety of Dongliyuan Health Care wine.Method Toxicity and mutation of the wine were detected according to assessment procedure and method of toxicology for food safety.Results LD₅₀to male and female mice was all greater than 40.0g/kg weight.It was classified as no toxicity.The result of blood cell micronucleus test of mice,malformation test of mice sperm and Ames test were negative.No mutation was observed.There was no significant difference in blood examination,biochemical detection,main organ check and histological examination between test and control groups（P>0.05）.Conclusion The results proved that Dongliyuan Health Care wine was safe as food.更多还原