【摘要】 目前,抗2型糖尿病药物主要有胰岛素分泌促进剂、胰岛素增效剂和影响糖吸收的药物。根据化学结构的不同,胰岛素分泌促进剂分为磺脲类和非磺脲类降糖药物;胰岛素增敏剂包括PPAR激动剂,3-胍丙酸及其衍生物,β₃-肾上腺素受体激动剂;影响糖吸收的药物分为双胍类和α-葡萄糖苷酶抑制剂。治疗糖尿病并发症的药物包括醛糖还原酶抑制剂和山梨醇脱氢酶抑制剂。更多还原

【Abstract】 The type 2 diabetes antagonists may be mainly classified as insulin secretagogues, insulin sensitizers and glucose absorption effecters. Based on the clarification of chemical structures, the insulin secretagogues include sulfonylureas and non-sulfonylureas. The insulin sensitizers are composed of PPAR agonists, 3-guanidino-propanoic acid and its derivatives, and β₃-adrenal receptor agonists The glucose absorption effecters have alpha-glucosidase inhibitors and bi-guanides. In addition, the aldose reductase inhibitors and sorbitol dehydrogenase inhibitors are clinically used to treat the diabetic complications. This review gave the current status of researches on these synthetic type 2 diabetes antagonists. The structure-function relationship and clinical therapeutics of these antagonists are addressed.更多还原