【摘要】 目的:采用Meta分析方法对左乙拉西坦辅助治疗成人癫痫部分发作的疗效和安全性进行评价。方法:查询Medline,EmBase,Cochrane图书馆等数据库收集文献。从符合标准的文献中提取癫痫发作频率减少50%和安全性数据,采用Review Manager软件进行统计计算。结果:检索到4篇左乙拉西坦的双盲、随机、安慰剂对照的临床试验。忽略剂量条件下,相对危险度(RR)和危险度差值(RD)分别为2.94[2.18,3.96]和0.24[0.19,0.29]。试验中出现的不良反应轻～中度,干预组的不良反应(嗜睡、疲劳、眩晕)发生率高于安慰剂组。结论:左乙拉西坦辅助治疗成人癫痫部分发作疗效肯定,耐受性良好。更多还原

【Abstract】 Objective:To make a Meta-analysis for the efficacy and safety of levetiracetam as an adjunctive therapy in adult patients with partial epilepsy. Methods: Using Medline, EmBase and the Cochrane Library database, the efficacy and safety information of 1023 patients who presented 50% less episode of their seizures post add-on treatments with levetiracetam were extracted from four randomized, double blind, placebo-controlled trials. Results: The analyses demonstrated that the relative risk and the risk difference in a 50% response to the treatment were 2.94 [2.18,3.961 and 0.24 [0.19,0.29] (95% CI), respectively, in the absence of dosing consideration. The risks in the incidence of mild to moderate adverse reactions in the add-on treatment group signified more than the placebo group with respect to somnolence, asthenia and dizziness. Conclusion: Levetiracetam offers an add-on alternative in the treatment of refractory partial seizures.更多还原