【摘要】 目的探讨腹腔镜和开腹直肠癌前切除对患者机体免疫功能的影响。方法2004年4月~2005年6月,我科行开腹和腹腔镜直肠癌前切除38例,腹腔镜组18例,开腹组20例。采用流式细胞仪测定外周血中CD3、CD4、CD8、NK细胞的百分比,采用免疫速率散射比浊法测定免疫球蛋白(IgA、M、G)以及补体C3、C4,以评定患者的免疫功能。结果患者术后24 h、96 h,开腹组和腹腔镜组CD3、CD4、CD8、血清免疫球蛋白及补体C3、C4同术前相比差异均无显著性。NK细胞,腹腔镜组术后24 h、96 h同术前相比差异无显著性,而开腹组明显低于术前。结论与开腹手术相比,腹腔镜下直肠癌前切除对患者NK细胞的影响少。更多还原

【Abstract】 Objective To compare effects of laparoscopic versus open anterior resection of rectal carcinoma on immune functions.Methods A total of 38 patients were given either laparoscopic（18 patients） or open（20 patients） anterior resection of rectal carcinoma from April 2004 to June 2005 in this department.The percentages of T-lymphocytes（CD₃,CD₄,and CD₈） and natural killer cells were calculated by using the flowcytometry.The levels of immunoglobins（IgG,IgA,and IgM） and complements（C₃ and C₄） were detected by using the immunonephelometry.Results In levels of T-lymphocytes,immunoglobins,and complements,there were no statistically significant differences between open and laparoscopic groups 24 and 96 hours after operation.In levels of natural killer cells,no differences were observed in laparoscopic group before and after operation（24 and 96 postoperative hours） while a significant decrease were found in open group after operation.Conclusions As compared with open surgery,laparoscopic anterior resection of rectal carcinoma has less influence on natural killer cells.更多还原