【摘要】 PKPD模型可用于优化兽药给药方案,制订合理的给药间隔和剂量,在减少细菌耐药性方面有重要意义。本文综述了β内酰胺类、氨基糖苷类、氟喹诺酮类、大环内酯类等抗微生物药物的PKPD研究现状,以期为兽药厂家在药物开发、设计合理的剂型与给药方案方面提供依据。更多还原

【Abstract】 The studies of pharmacokinetic-pharmacodynamics integration have important value on the design of antimicrobial regimen, thus directing rational adminstration and avoiding drug resistance. This review is mainly about PK-PD researches on beta lactams, aminoglycosides, fluoroquinolones, macrolides, etc. Hopefully it will be helpful for veterinary companies in developing new drugs and acquiring optimal regimen.更多还原