【摘要】 目的观察肺癌平对Lewis肺癌小鼠肿瘤细胞凋亡的影响。方法选用Lewis肺癌小鼠肿瘤细胞株,制作肿瘤动物模型后,分为盐水对照组、肺癌平组,进行光、电镜形态学观察。结果实验组在20只受试Lewis肺癌小鼠中发癌数为16只,而对照组20只全部发癌,且与对照组比较,肿瘤团块较小,病理性核分裂较少,间质血管较少,淋巴细胞浸润。电镜下可见凋亡小体形成,且肺癌平能刺激淋巴细胞增生,在癌细胞间有许多淋巴细胞浸润,可见淋巴细胞侵入癌细胞并直接攻击破坏癌细胞。结论肺癌平具有抗肺癌作用,其作用机理是通过诱导肿瘤细胞凋亡及刺激淋巴细胞增生的作用而实现的。更多还原

【Abstract】 Objective:To investigate the effect of Feiai Ping on inducing cell apoptosis of Lewis lung cancer mouse.Methods:We chose the cell strain of Lewis lung cancer mouse,inoculated the cell strain subcutaneously.After building the tumor animal model successfully,we divided the animal into Saline control group and Feiai Ping treating group.Using the method of light microscope(LM) and electron microscope(EM) to observe the morphology.Results:Feiai Ping treating group has 16 episode mice,while the control group has 20 samples.To be compared with the control group,the experimental group has following characteristics:the tumor ball and the cell volum are smaller,the atypia is not evident,and the pathological karyokinesis and interstitial blood vessel are fewer.It has necrosis and infiltration of lymphocyte.Through the observation of EM,we found the formation of apoptotic body.In addition,the Feiai Ping can activate the proliferation of lymphocyte.There are many lymphocytes between the tumor cells and the lymphocytes invade the tumor cells to destroy the tumor cells.Conclusion:Feiai Ping has the function of anti-lung cancer which mechanism maybe induce the tumor cell apoptosis of the Lewis lung cancer mouse and activate the proliferation of lymphocyte.更多还原