【摘要】 目的　分析3年中1 878株非发酵菌感染的耐药情况,探讨合理使用抗菌药物。方法　回顾性总结2001~2003年我院重症治疗中心共计分离出的1 878 株非发酵菌,对其分布特点、检出率及药敏结果进行统计、分析。结果　重症治疗中心内医院感染非发酵菌检出率为43.36%,其中铜绿假单胞菌最为常见(19.75%),其次为鲍氏不动杆菌(15.18%),近年来,嗜麦芽寡养单胞菌呈上升趋势,其检出率约为5.38%;不同感染部位标本非发酵菌检出的阳性率也不同,以呼吸系统最为常见,占79.4%,尿液与引流液阳性率约为23.3%;铜绿假单胞菌和鲍氏不动杆菌在临床表现出较高的耐药性,临床较为敏感的药物包括亚胺培南、头孢哌酮/舒巴坦等含酶抑制剂的复合型抗菌药物;嗜麦芽寡养单胞菌对亚胺培南天然耐药,药敏结果显示复方新诺明、头孢哌酮/舒巴坦、替卡西林/克拉维酸敏感。结论　重症治疗中心医院感染中非发酵菌检出率高且耐药性强,以头孢哌酮/舒巴坦为代表的含酶抑制剂的复合型抗菌药物,对非发酵菌显示出较高的敏感性和较低的耐药性。更多还原

【Abstract】 OBJECTIVE To evaluate the antimicrobial resistance of nonfermentaters and antibiotics therapy in ICU. METHODS We analyzed the distribution and antimicrobial resistance of 1 878 identified nonfermentaters in ICU from Jan 2001 to Dec 2003. RESULTS The isolation rate of nonfermentaters in ICU was 43.36%, the most common pathogen was Pseudomonas aeruginosa (19.75%), the next was Acinetobacter baumannii (15.18%) and Stenotrophomonas maltophilia (5.38%). The bacterial isolation rate was different in sites, the respiratory system had the highest bacterial isolation rate, about 79.4%. CONCLUSIONS The isolation rate of nonfermentaters is ratherhigh in nosocomial infection in patients of ICU. The nonfermentaters have high sensitive rate and low antimicrobialresistance rate to cefoperazone/sulbactam.更多还原