【摘要】 目的:研究繁缕Stellaria media(L.)Cyr.的水溶性化学成分。方法:运用多种层析分离方法进行分离纯化,并用波谱数据和理化常数进行对照,确定化合物的结构。结果:从繁缕新鲜药材的汁液中分离并鉴定了21个化合物,分别为:环(亮-异亮)二肽(1),环(缬-酪)二肽(2),α-乙基-D-吡喃半乳糖苷(-αethyl-D-pyrano-galactoside,3),尿嘧啶(uracil,4),胸腺嘧啶(thymine,5),胸苷(thymidine,6),鸟苷(guanosine,7),2-氯-腺苷(2-chloroadenosine,8);另外还分离并鉴定了13个氨基酸(化合物9~21),包括11个常见氨基酸和2个特殊氨基酸,分别为:天冬氨酸,谷氨酸,丙氨酸,丝氨酸,缬氨酸,亮氨酸,甘氨酸,苏氨酸,酪氨酸,赖氨酸,组氨酸,γ-氨基丁酸及α-氨基-γ-羟基-戊二酸。结论:此21个化合物均为首次从该植物中分离得到。更多还原

【Abstract】 AIM:To investigate the chemical constituents from Stellaria media（L.） Cyr..METHODS:Column chromatography(silica gel,C₁₈ and Sephadex LH-20) was used to separate the chemical constituents whose structures were determined by spectral analyses(¹H NMR,¹³C NMR,MS and IR).RESULTS:Twenty-one compounds were isolated and identified as cyclo-（Leu-Ile）,cyclo-（Val-Tyr）,α-ethyl-D-pyrano-galactoside,uracil,thymine,thymidine,guanosine,2-chloroadenosine.Aspartic acid,glutamic acid,alanine,serine,valine,leucine,glycine,threonine,tyrosine,lysine,histidine,proline,γ-amino-butyric-acid,and α-amino-glutamic acid.CONCLUSION:All of the compounds were isolated from this plant for the first time.更多还原