【摘要】 目的　研究糖耐量受损(IGT)者的胰岛素抵抗(IR)及胰岛β细胞功能变化。　方法　选取正常糖耐量(NGT)、IGT、2型糖尿病(T2DM)者共34 例,以高胰岛素正血糖钳夹技术测定IR,行静脉葡萄糖耐量试验评估胰岛β细胞分泌功能。　结果　与NGT组相比,IGT组、T2DM组的IR显著升高;IGT组胰岛素第一时相分泌明显下降,空腹胰岛素(FIns)水平及第二时相分泌水平升高;T2DM组IR与IGT组处于同一水平,FIns较NGT组显著减少。　结论　由NGT向IGT的演变过程中,IR和胰岛素分泌缺陷共同起作用。更多还原

【Abstract】 Objective To study insulin resistance and beta-cell function of Shenyang subjects with impaired glucose tolerance （IGT） and to investigate the pathogenesis of type 2 diabetes mellitus （T2DM）. Methods We performed the study in a total of 34 subjects with varying degree of glucose tolerance （12 subjects with normal glucose tolerance （NGT）, 14 with IGT, and 8 with DM）. Insulin resistance was measured using hyperinsulin-euglycemic clamp, and beta-cell function was assessed by intraveneous glucose tolerance test. Results Compared with the NGT group, the subjects with IGT had significantly lower glucose infusion rate (GIR, mg·kg^-1·min^-1) （5.1±0.6 vs 10.1±1.0, P<0.01）, significantly increased fasting plasma insulin level （28.1±3.4 vs 12.6±1.1 mU/L, P<0.01）, markedly reduced first-phase insulin secretion （11.3±2.9 vs 43.0±9.6 mU/L, P<0.01） and markedly elevated second-phase insulin secretion （35.3±7.3 vs 15.3±2.0 mU/L,P<0.01）. The GIR in the subjects with DM was as great as that in those with IGT （4.5±0.4 vs 5.1±0.6, P=0.53 ）, but fasting plasma insulin level in the DM group was significantly lower than that in the IGT group（13.9±1.1 vs 28.1±3.4 mU/L, P<0.01）. Conclusion Both insulin resistance and insulin secretion dysfunction are associated with the transition from NGT to IGT in Chinese northeast （subjects.）更多还原