【摘要】 目的　探讨饮酒与上海市市区中老年男性死亡的关系。方法　自 1986年 1月～ 1989年 9月调查上海市区 4 5～ 6 4岁男性居民 182 4 4人 ,每年上门随访一次 ;用COX比例风险模型计算相对危险度。结果　至 2 0 0 2年度随访结束 ,全队列共随访 2 35 76 2人年 ,人均随访 12 .9年。在此期间共死亡 336 5人 ,其中恶性肿瘤死亡 1381人。在调整年龄、吸烟情况及教育程度后 ,相对于不饮酒者每天饮酒酒精量 <15 g和 15～ 2 9g者总死亡相对危险度 (RR)分别为 0 .80 (95 %CI:0 .72～ 0 .89)和 0 .87(95 %CI :0 .78～ 0 .97) ,每天饮酒酒精量 90 g及以上者RR为 1.2 5 (95 %CI:1.0 4～ 1.5 1)。少量饮酒者缺血性心脏病和慢性阻塞性肺部疾病死亡危险性显著降低。每天饮酒酒精量 70 g及以上者食管癌、结直肠癌、脑血管病死亡危险性显著升高 ,RR分别为 5 .0 8,2 .5 7和 1.5 7,肝硬化死亡危险性在每天饮酒酒精量 30 g及以上者中也显著上升 ,RR为 1.89。 结论　少量饮酒会降低中老年男性总死亡危险性 ,大量饮酒则会增加中老年男性食管癌、结直肠癌、脑血管病及肝硬化的死亡危险性。更多还原

【Abstract】 Objective To access the association between alcohol consumption and mortality in men in urban Shanghai.Methods A total of 18?244 male residents of urban Shanghai aged 45 to 64 years were enrolled in the study during January 1,1986 through September 30,1989,and were actively followed up via annual visits.Cox proponional hazards model was used to estimate the relative risks ( RR ).Results By the end of follow-up in 2002,the cohort was followed up with involvement of 235 762 person-years,averaged 12.9 years per subject.3 365 deaths including 1 381 from cancer were registered during the follow-up period.Compared with lifelong non-drinkers,the RR of overall mortality among those who drank <15grams,15-29 grams ethanol per day was 0.80(95% CI ):0.72-0.89) and 0.87(95% CI :0.78-0.97),respectively; the RR among those drinking 90 grams or more ethanol per day was 1.25(95% CI :1.04-1.51).Among light drinkers the mortality of ischemic heart disease and chronic obstructive pulmonary disease decreased significantly.Drinking 70 grams or more ethanol per day was significantly associated with increased risks of death from esophageal cancer ( RR 5.08),colorectal cancer ( RR 2.57),and stroke ( RR 1.57).The risk of death from hepatic cimhosis also rose significantly in those who drank 30 grams or more ethanol per day ( RR 1.89).Conclusion Light drinking is associated with lower overall mortality in middle-aged and elderly men,while heavy drinking is associated with increased risk of death from esophageal cancer,colorectal cancer,stroke,and hepatic cirrhosis.更多还原