【摘要】 目的了解贵州省从江县翠里村“精神与智力障碍”人群发病情况,为确诊与病因调查提供线索。方法对“精神与智力障碍”人群进行体格检查及流行病学个案调查,对目标人群(育龄妇女和8～10岁儿童)进行尿碘、甲状腺肿大率、智商以及居民家中食盐含碘量检测。结果病人家族中无近亲婚史和有关疾病家族史,无遗传、家庭聚集现象,人群分布主要是男性,年龄分布主要在20岁以上人群,22人中有21人具有克汀病病人表现,8～10岁儿童甲状腺肿大率(甲肿率)5.88%,尿碘中位数184.9μg/L,智商值(IQ)均数86.8;育龄妇女尿碘中位数174.6μg/L,盐碘均值23.9mg/kg。结论该村目前无克汀病发病的基础,该村34例“精神与智力障碍”病人有可能是过去发病的克汀病病人。更多还原

【Abstract】 Objective To investigate the status of patients with mental retardation in Cuili village ofCongjiang, Guizhou Province so as to find a clue for diagnosis and etiologic study. Methods Epidemiological casesurvey and physical examination were performed in patients with mental retardation. In addition, urinary iodine, goiterrate and intelligence quotient were detected in target population of both children aged 8 ￣ 10 and childbearing women.Also, iodine content in their table salt was detected. Results There existed neither family history of consanguineousmarriage and related disease, nor phenomenon of inheritance and family cluster among the patients. The patientsmostly were male and older than 20 years old. 21 out of 22 presented cretin manifestations, accounting for 95.5%. Inchildren aged 8 ￣ 10 years old, the prevalence of goiter was 5.88%, average of intelligence quotient (IQ) was 86.88.The median of urinary iodine (MUI) were 184.9 μg/L and 174.6 μg/L in schoolchildren and adults, respectively. Themedian of iodized salt in households was 23.9mg/kg. Conclusions At present, the population in Cuili village is inbetter iodine nutrition status. The patients with mental retardation are those who previously suffered from cretin.更多还原