【摘要】 目的探讨纳洛酮治疗亚临床型肝性脑病(SHE)的疗效。方法69例SHE按双盲法随机分为治疗组及对照组二组,分别给予纳洛酮0.4mg、0.9%氯化钠静脉推注,连用5-10天,用药前后分别作数字连接试验(NCT)、数字符号试验(DS)、脑干诱发电位(BAEP),并随访有否发性临床型肝性脑病。结果治疗组治疗后各项指标均较治疗前有明显改善,且随访无一例发生肝性脑病,对照组治疗前后各项指标改善不明显,且随诊有3例发生临床型肝性脑病。结论纳洛酮是一种对SHE治疗有效的药物。更多还原

【Abstract】 Objective To evaluate the naloxone on cirrhotic patients w ith subclinical hepatic encephalopathy (SH E).M ethods 67 patients w ith SH E random ized double-blind design was used to assign in the experim ental groupand the control group. In the experim ental group, the patients were given 0.4m g of naloxone inject vein once adays, the controls group were given norm al saline inject vein. num ber connection test(N C T), digit sym bol test(D S)and som atosensory audbrainstem auditory evoked potentials (BAEP)w ere perform ed in all patients before and afterthe treatm ent. The clinical mental status w as also observed. Results In the experim ental group, All data im proveevidence before the treatm ent. N o developed hepatic encephalopathy w as found and the N C T and DSsignificantlyafter treatm ent. In the control group, All data did not change significantly after treatm ent and three patients devel-oped hepatic encephalopathy. Conclusion naloxone is a effective m edicam ent in treating SHE.更多还原